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目的:探讨连续性与间歇性肾脏代替法对重症急性肾功能衰竭患者远期生存率及并发症的影响。方法:抽取2013年8月至2015年1月滨州市中心医院收治的重症急性肾功能衰竭患者95例，其中47例行间歇性肾脏代替法治疗者纳入对照组，48例行连续性肾脏代替法治疗者纳入观察组。比较两组临床疗效、肾功能指标、并发症及5年生存率。结果:观察组总有效率(85.42%，41/48)高于对照组(68.09%，32/47), χn 2＝4.009，n P＝0.045。治疗6个月，两组血肌酐、尿素氮水平低于治疗前，且观察组肾功能指标改善更明显(n t＝8.260、30.772，n P<0.05)。观察组并发症发生率(10.42%，5/48)较对照组(23.40%，11/47)低，χn 2＝4.598，n P＝0.032。观察组5年生存率(89.58%，43/48)略高于对照组(80.85%，38/47)，但差异未见统计学意义(χn 2＝2.860，n P＝0.091)。n 结论:与间歇性肾脏代替法比较，连续性肾脏代替法治疗重症急性肾功能衰竭可改善患者肾功能，减少并发症，稳定远期生存率。“,”Objective:To investigate the effects of continuous and intermittent renal replacement on long-term survival rate and complications in patients with severe acute renal failure.Methods:A total of 95 patients with severe acute renal failure admitted to Binzhou Central Hospital from August 2013 to January 2015 were selected. Among them, 47 patients who received intermittent renal replacement therapy were included in the control group, and 48 patients who received continuous renal replacement therapy were included in the observation group. The clinical efficacy, renal function indexes, complications and 5-year survival rate were compared between the two groups.Results:The total effective rate in the observation group (85.42%, 41/48) was higher than that in the control group (68.09%, 32/47), χ n 2=4.009, n P=0.045. After 6 months of treatment, the levels of serum creatinine and urea nitrogen in the two groups were lower than those before treatment, and the renal function indexes of the observation group improved significantly (n t=8.260, 30.772, n P<0.05). The complication rate in the observation group (10.42%, 5/48) was lower than that in the control group (23.40%, 11/47), χn 2=4.598, n P=0.032. The 5-year survival rate in the observation group (89.58%, 43/48) was higher than that in the control group (80.85%, 38/47), but with not significant difference (χn 2=2.860, n P=0.091).n Conclusions:Compare with the intermittent renal replacement therapy, the continuous renal replacement therapy for severe acute renal failure can improve the renal function of patients, reduce complications, and stabilize the long-term survival rate.