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目的:探讨调肝导浊中药防治动脉粥样硬化的机理。方法:运用体外培养技术,以加高脂血清和中药等不同培养基培养小鼠腹腔巨噬细胞,检测细胞培养液中一氧化氮(NO)、一氧化氮合酶(NOS)、氧化修饰低密度脂蛋白(OX-LDL)等指标。结果:调肝导浊中药可明显增加细胞培养液中 NO、NOS 的含量,并可抑制 OX-LDL 生成。结论:该中药通过对 NO、NOS、OX-LDL 含量的调节,阻止动脉粥样硬化(AS)的发生及发展。
Objective: To investigate the mechanism of prevention and treatment of atherosclerosis by Tiaoganzhuozhu. METHODS: In vitro culture techniques were used to culture mouse peritoneal macrophages with different media such as hyperlipidemia serum and traditional Chinese medicine. Nitric oxide (NO), nitric oxide synthase (NOS), and oxidative modification were detected in cell culture fluids. Density lipoprotein (OX-LDL) and other indicators. Results: Liver-regulating and turbidity-removing Chinese herbs can significantly increase the content of NO and NOS in the cell culture fluid and inhibit the production of OX-LDL. Conclusion: The traditional Chinese medicine prevents the occurrence and development of atherosclerosis (AS) by regulating the levels of NO, NOS and OX-LDL.