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目的分析亚临床甲状腺功能减退症(亚临床甲减)患者血脂水平变化及临床意义。方法测定52例亚临床甲减患者、60例健康对照组和55例临床甲减组的血清促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平,比较其结果的差异。结果与对照组相比:临床甲减组与亚临床甲减组的LDL-C、TSH明显升高,有非常显著性差异(P<0.01);临床甲减组的FT4、TC、TG明显升高,有非常显著性差异(P<0.01);亚临床甲减组的TC和临床甲减组的FT3升高,差异有显著性(P<0.05)。与亚临床甲减组相比:临床甲减组的FT4、TC、TG明显升高,有非常显著性差异(P<0.01),TSH、FT3升高,差异有显著性(P<0.05)。各组的HDL-C差异无统计学意义。结论亚临床甲减可以引起血脂代谢异常,并且部分血脂指标接近临床甲减。
Objective To analyze the changes of blood lipid levels in patients with subclinical hypothyroidism (subclinical hypothyroidism) and its clinical significance. Methods Serum thyrotropin (TSH), free triiodothyronine (FT3) and free tetraethionine (SAH) in 52 patients with subclinical hypothyroidism, 60 healthy controls and 55 patients with clinical hypothyroidism were measured. FT4), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) Results Compared with the control group, LDL-C and TSH in clinical hypothyroidism group and subclinical hypothyroidism group were significantly increased (P <0.01), FT4, TC and TG in clinical hypothyroidism group were significantly increased (P <0.01). The TCs in subclinical hypothyroidism group and FT3 in clinical hypothyroidism group were significantly higher than those in control group (P <0.05). Compared with the subclinical hypothyroidism group, FT4, TC and TG in the clinical hypothyroidism group were significantly increased (P <0.01), TSH and FT3 increased, the difference was significant (P <0.05). There was no significant difference in HDL-C between groups. Conclusion Subclinical hypothyroidism can cause dyslipidemia, and some blood lipid indicators close to clinical hypothyroidism.