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目的奥扎格雷钠联合银杏达莫治疗急性脑梗死患者的疗效及其对血液流变学的影响。方法选取2015年1月至2016年3月于辽宁省铁岭市中心医院实施治疗的98例急性脑梗死患者作为研究对象,随机将其分为研究组和对照组,各49例。对照组患者使用血塞通注射液联合丹参注射液进行治疗,研究组患者则采用注射用奥扎格雷钠联合银杏达莫进行治疗,比较两组患者治疗效果、治疗前后神经功能缺损程度及血液流变学指标变化情况。结果研究组患者治疗的总有效率显著高于对照组,差异有统计学意义(P<0.05);治疗后,研究组患者的神经功能缺损评分量表(NDS)评分明显低于对照组,差异有统计学意义(P<0.05);治疗后,研究组患者全血黏度、血浆黏度、血小板聚集数、红细胞压积、红细胞聚集指数均明显低于对照组,差异均有统计学意义(均P<0.05)。结论采用银杏达莫联合奥扎格雷钠治疗急性脑梗死临床效果显著,能有效改善患者血液流变学指标,促进神经功能缺损恢复。
Objective To investigate the curative effect of ozagrel combined with ginkgo biloba on patients with acute cerebral infarction and its effect on hemorrheology. Methods A total of 98 patients with acute cerebral infarction who were treated in Central Hospital of Tieling, Liaoning Province from January 2015 to March 2016 were randomly divided into study group and control group, with 49 cases in each group. Patients in the control group were treated with Xuesaitong injection combined with Salvia miltiorrhiza injection. Patients in the study group were treated with ozagrel sodium and ginkgo-dipyridamole injection. The therapeutic effect was compared between the two groups before and after treatment, the degree of neurological deficits and blood flow Changes in indicators of change. Results The total effective rate of treatment in study group was significantly higher than that in control group (P <0.05). After treatment, the score of NDS in study group was significantly lower than that of control group (P <0.05). After treatment, the whole blood viscosity, plasma viscosity, platelet aggregation, hematocrit and erythrocyte aggregation index of the study group were significantly lower than those of the control group (all P <0.05). Conclusions The clinical effect of combining ginkgoldol and ozagrel sodium in the treatment of acute cerebral infarction is significant, which can effectively improve the hemorheological parameters and promote the recovery of neurological deficits.