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目的：研究子宫内膜癌ｐ５３蛋白过度表达与性激素受体阳性的关系。方法：收集４５例子宫内膜癌手术标本，采用多种ＰＡＰ免疫组化方法进行检测。结果：４５例宫内膜癌中１４例（３１．１％）ｐ５３蛋白过度表达，其中１１例雌、孕激素受体阴性，而在ｐ５３阴性的３１例中２７例雌、孕激素受体阳性。在子宫内膜癌中ｐ５３蛋白过度表达与雌、孕激素受体呈负相关（Ｐ＜０．０１）。结论：部分子宫内膜癌的发生可能与雌激素受体无关，而与ｐ５３蛋白过度表达有关。
Objective: To study the relationship between p53 protein overexpression and sex hormone receptor positive in endometrial cancer. Methods: 45 cases of endometrial cancer surgical specimens collected using a variety of PAP immunohistochemistry for detection. Results: p53 protein was overexpressed in 14 cases (31.1%) of 45 cases of endometrial carcinoma, of which 11 cases were negative for estrogen and progesterone receptors and 27 cases were positive for estrogen and progesterone receptors in 31 cases of p53 negative . In endometrial cancer, p53 protein overexpression was negatively correlated with estrogen and progesterone receptors (P <0.01). Conclusion: The occurrence of some endometrial carcinomas may not be related to the estrogen receptor but to the overexpression of p53 protein.