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目的探讨血管生成素-2(Ang-2)在晚期原发性肝癌组织和正常肝脏组织中的表达及其意义。方法采用免疫组织化学染色SP法检测50例晚期肝癌(HCC)组织切片(其中36例直径>5 cm,14例直径<5 cm;12例伴有区域淋巴结转移,38例无区域淋巴结转移)和20例正常肝脏组织(对照组)中Ang-2抗体的表达水平。结果肿瘤直径>5 cm肝癌组中Ang-2表达均强于直径<5 cm肝癌及对照组(P<0.05),肿瘤直径<5 cm肝癌组Ang-2表达强于对照组(P<0.05);有区域淋巴结或肝内转移组Ang-2表达强于无转移组(P<0.05)。结论在肝癌发展中,患者肝脏内Ang-2表达明显增加,其增加的程度与肿瘤生长和侵袭转移密切相关。
Objective To investigate the expression and significance of angiopoietin-2 (Ang-2) in advanced primary hepatocellular carcinoma and normal liver tissues. Methods Tissue sections of 50 patients with advanced hepatocellular carcinoma (HCC) were studied by immunohistochemical SP method (36 cases with diameter> 5 cm, 14 cases with diameter <5 cm, 12 cases with regional lymph node metastasis and 38 cases without regional lymph node metastasis) and The expression level of Ang-2 antibody in 20 normal liver tissues (control group). Results The expression of Ang-2 in HCC with tumor diameter> 5 cm was stronger than that in HCC <5 cm and control group (P <0.05). The expression of Ang-2 in HCC with tumor diameter <5 cm was stronger than that in control group (P <0.05) ; Ang-2 expression in regional lymph node or intrahepatic metastasis group was stronger than that in non-metastasis group (P <0.05). Conclusions In the development of liver cancer, the expression of Ang-2 in the liver of patients is obviously increased. The extent of its increase is closely related to tumor growth and invasion and metastasis.