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目的 研究慢性乙型肝炎肝组织中白细胞介素 1 2 (IL 1 2 )的表达与干扰素 (IFN)疗效的关系。方法 用免疫组织化学方法检测肝组织中IL 1 2。结果 干扰素治疗有效组 (1 4例 )与无效组 (8例 )之间肝组织中IL 1 2的表达量之间差异有显著意义 (H =59,P <0 0 5)。结论 IL 1 2有助于临床IFN α治疗乙型肝炎的决策
Objective To investigate the relationship between the expression of interleukin-12 (IL-12) and the efficacy of interferon (IFN) in chronic hepatitis B liver tissue. Methods Immunohistochemistry was used to detect IL-12 in liver tissue. Results There was a significant difference in the expression of IL-12 in liver tissue between effective interferon group (14 cases) and ineffective group (8 cases) (H = 59, P <0 05). Conclusion IL-1 2 contributes to the clinical decision of treatment of hepatitis B with IFN-α