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目的:对辛伐他汀药物的相互作用处方进行分析。方法:选取2014年6月-2015年5月我院门诊含有的辛伐他汀处方,并分析与辛伐他汀药物合用药物具有相互作用的处方。结果:本院门诊含有辛伐他汀处方一共1837张,其中单独开具辛伐他汀的有408张,占含有辛伐他汀处方总数的22.2%;而辛伐他汀与其他药物合开的有1429张,占含有辛伐他汀处方总数的77.8%。与辛伐他汀合用的CYP3A4抑制剂药物共7种,共计处方46张;与辛伐他汀合用的CYP3A4底物共10种,共计处方329张;其他与辛伐他汀具有相互作用的药物共计处方28张。结论:辛伐他汀能有效地治疗高胆固醇血症,但也能带来严重的不良反应,尤其是与其他药物的联用将会大大地增加药物的相互作用。因此门诊医师在开处方时,要详细地询问患者的既往病史以及联合用药的情况,必要时要监测肝功(AST,ALT)和肌酸肌酶(CK),并注意调整用药剂量,服药时间,以降低辛伐他汀药物的不良反应。
Objective: To analyze the prescription of simvastatin drug interaction. Methods: The prescriptions of simvastatin contained in the outpatient department of our hospital from June 2014 to May 2015 were selected and the prescriptions interacting with simvastatin drugs were analyzed. Results: There were 1837 prescriptions for simvastatin in our outpatient clinic, of which 408 were simvastatin alone, accounting for 22.2% of the total number of simvastatin medications. Simvastatin was administered in combination with 1429 other drugs, Accounting for 77.8% of the total number of simvastatin-containing prescriptions. There were 7 CYP3A4 inhibitor drugs combined with simvastatin, a total of 46 prescriptions; 10 CYP3A4 substrates combined with simvastatin, for a total of 329 prescriptions; other drugs that interact with simvastatin Total prescription 28 Zhang Conclusion: Simvastatin can effectively treat hypercholesterolemia, but it can also cause serious adverse reactions. In particular, the combination with other drugs will greatly increase the drug interactions. Therefore, when prescribing an outpatient, patients should be asked in detail about their past medical history and the situation of combination therapy. Liver function (AST, ALT) and creatine kinase (CK) should be monitored when necessary. Attention should be paid to adjusting dosage, To reduce the adverse reactions of simvastatin drugs.