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目的:探讨妊娠期急性白血病患者的临床特点、诊断和治疗措施。方法:回顾性分析中国科学技术大学附属第一医院2009年1月至2018年12月妊娠期间确诊急性白血病16例患者的临床资料。分析患者诊疗方案、妊娠结局、胎儿情况及患者生存情况。结果:16例患者均行骨髓穿刺明确诊断白血病并分型，其中急性髓系白血病13例（非急性早幼粒细胞白血病5例，急性早幼粒细胞白血病8例），急性淋巴细胞白血病3例。确诊时，处于妊娠早期6例，妊娠中期6例，妊娠晚期4例。妊娠结局：自然分娩1例，剖宫产5例，人工流产9例，自然流产1例。妊娠期间化疗15例，11例在妊娠结束后继续行原发病化疗，3例在治疗期间死亡。13例随访患者中生存8例，失访5例。结论:妊娠期急性白血病的早期诊断很重要，产检发现血常规异常时应及时进行骨髓穿刺以明确诊断。应及时启动多学科会诊，制定最佳治疗方案。“,”Objective:To explore the clinical characteristics, diagnosis and treatment of acute leukemia patients during pregnancy.Methods:The clinical data of 16 cases with acute leukemia during pregnancy from January 2009 to December 2018 in the First Affiliated Hospital of USTC were retrospectively analyzed. The diagnosis and treatment regimens, pregnancy outcome, the early fetus and survival status of patients were also analyzed.Results:All 16 leukemia cases were confirmedly diagnosed and classified by bone marrow puncture, including 13 cases of acute myeloid leukemia (5 cases of non-acute promyelocytic leukemia and 8 cases of acute promyelocytic leukemia) and 3 cases of acute lymphoblastic leukemia. At the time of confirmed diagnosis, 6 patients were in first trimester, 6 cases in second trimester and 4 cases in late trimester. As for pregnancy outcome, 1 patient had natural birthing, 5 patients underwent cesarean operation, 9 patients underwent artificial abortion and 1 patient had spontaneous abortion. Chemotherapy was performed in 15 patients during pregnancy, 11 patients received chemotherapy for treatment of primary disease after pregnancy, 3 patients died during the treatment. During the follow-up of 13 cases, 8 patients survived and 5 patients lost follow-up.Conclusions:Early diagnosis of acute leukemia during pregnancy is very important. Bone marrow puncture should be performed timely to make clear diagnosis when blood routine result is abnormal during antenatal care. Multidisciplinary consultation should be initiated in time, and the best treatment plan should be worked out to guard against serious complications during pregnancy.