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为证实生长抑素对Ｏｄｄｉ括约肌功能的作用，用逆行胰胆管造影下Ｏｄｄｉ括约肌测压研究了生长抑素对２０例患者Ｏｄｄｉ括约肌运动功能的影响。２０例患者中胆总管结石６例，胆总管轻度扩张３例，肝门癌３例，未见明显异常者８例。用低顺应性水灌注系统，三通道测压导管，分别于用药前及静注生长抑素２５０μｇ，１ｍｉｎ后进行Ｏｄｄｉ括约肌测压，以观察Ｏｄｄｉ括约肌的基础压、收缩频率、收缩幅度、收缩间期、传播方式和胆管内压变化。结果显示：用药后Ｏｄｄｉ括约肌基础压降低、收缩频率减慢，其余指标无明显变化。我们认为：生长抑素对Ｏｄｄｉ括约肌有抑制性作用，有利于胆汁和胰液的排出。
In order to confirm the effect of somatostatin on the function of Oddi sphincter, the effect of somatostatin on the motor function of Oddi sphincter in 20 patients was investigated by Oddi sphincter pressure under retrograde cholangiopancreatography. Twenty patients had choledocholithiasis in 6 cases, mild dilatation in 3 cases, hilar carcinoma in 3 cases, and no obvious abnormalities in 8 cases. Oddi sphincter pressure measurement was performed before and after intravenous infusion of somatostatin 250 μg and 1 min respectively to observe the basal pressure, the frequency of contractions, the amplitude of contraction and the amplitude of contraction in the Oddi sphincter with low compliance water perfusion system and three-channel manometry catheter. Period, mode of transmission and changes in bile duct pressure. The results showed that the basic pressure of Oddi sphincter decreased and the frequency of contractions slowed down after treatment, and the other indexes did not change significantly. We think: somatostatin inhibitory effect on Oddi sphincter, is conducive to the excretion of bile and pancreatic juice.