小儿肾病综合征血浆脂蛋白a测定

• 作 者: 韩子明 杨达胜 付素珍 陈新德
• 机 构: 河南省卫辉市新乡医学院第一附属院儿科,河南省卫辉市新乡医学院第一附属院儿科,河南省卫辉市新乡医学院第一附属院儿科,河南省卫辉市新乡医学院第一附属院儿科 卫辉 453100,卫辉 453100,卫辉 4
• 出 处: 陕西医学杂志
• 发表日期: 2000年07期
• 关键词: 儿童 肾变病综合征/血液 脂蛋白类 高密度/分析

对42例临床诊断为肾病综合征的住院患儿检测血脂及用免疫比浊法测定Lp(a),并以25例同期上感儿童作为对照组。结果对照组血浆 Lp(a)为210±26mg/L,肾病期为422±68mg/L,肾病缓解期为304±37mg/L。肾病综合征肾病期和缓解期Lp(a)均高于对照组(P<0.01),而肾病期又高于缓解期。Lp(a)与TC,TG,LDL-C,ApoB,24h尿蛋白呈正相关,与血总蛋白,白蛋白呈负相关。提示在临床上对肾病综合征的脂质代谢紊乱有必要进行降脂治疗,防止肾小球疾病的进展。

Twenty-two inpatients with nephrotic syndrome were tested for serum lipids and Lp (a) by immunoturbidimetry. Twenty-five children with concomitant upper extremities were selected as control group. Results The plasma Lp (a) was 210 ± 26 mg / L in the control group, 422 ± 68 mg / L in the nephropathy stage, and 304 ± 37 mg / L in the nephropathy stage. Nephrotic syndrome nephropathy and remission Lp (a) were higher than the control group (P <0.01), while the nephropathy was higher than the remission. Lp (a) was positively correlated with TC, TG, LDL-C, ApoB and 24h urinary protein, but negatively correlated with serum total protein and albumin. Prompted in the clinical nephrotic syndrome lipid metabolism disorders necessary lipid-lowering therapy to prevent the progression of glomerular diseases.