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目的：探讨新生儿窒息血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）及降钙素基因相关肽（ｃａｌｃｉｔｏｎｉｎｇｅｎｅｒｅｌａｔｅｄｐｅｐｔｉｄｅ，ＣＧＲＰ）的变化。方法：对２４例足月新生儿窒息患儿及１８例对照新生儿，用放射免疫学方法测定出生后第１天和第５天血浆ＥＴ１及ＣＧＲＰ浓度。结果：生后第１天窒息患儿血浆ＥＴ１及ＣＧＲＰ水平均显著高于对照组；生后第５天患病组二者水平显著下降。实验组第１、５天血浆ＥＴ１及ＣＧＲＰ呈正相关性。结论：新生儿窒息血浆ＥＴ生成增加可能起着损伤机体的作用；而ＣＧＲＰ升高可能是机体的自我保护机制。
Objective: To investigate the changes of plasma endothelin (ET) and calcitonin gene related peptide (CGRP) in neonates with asphyxia. Methods: Twenty-four neonates with full-term neonatal asphyxia and 18 newborns with normal controls were enrolled. Plasma ET-1 and CGRP concentrations were measured by radioimmunoassay on day 1 and day 5 after birth. Results: The levels of plasma ET-1 and CGRP in children with asphyxia on the first day after birth were significantly higher than those in the control group. The level of ET-1 and CGRP on the 5th day after birth significantly decreased in both groups. The experimental group on the first day 1,5 plasma ET 1 and CGRP was positively correlated. Conclusion: Increased ET production in neonatal asphyxia may play a role in damaging the body. Elevated CGRP may be the mechanism of self-protection of the body.