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目的:探讨事件相关电位(ERP)的P300成分检测对癫癎儿童认知功能的评价。方法:利用ERP、韦氏儿童智力量表中国修订版(WIS-CR)对32例癫癎儿童进行P300测定和心理评估,以28例性别、年龄相匹配的正常儿童作对照。结果:与正常对照组比较,癫癎组儿童总智商(FIQ)、语言智商(VIQ)和操作智商(PIQ)得分均明显降低(P<0．01),32例癫癎患儿中有28％有智能障碍;ERP的P300波潜伏期也明显延长,P<0．01。结论:癫癎儿童易发生智力障碍,P300波潜伏期检测能早期、客观、准确地评价癫癎儿童的认知功能状况。
Objective: To investigate the assessment of the cognitive function of children with epilepsy by detecting P300 of incident-related potentials (ERP). Methods: P300 and psychological assessment were performed on 32 children with epilepsy by using WIS-CR and ERP, and 28 normal children of the same sex were matched as controls. Results: Compared with the normal control group, the scores of FIQ, VIQ and PIQ in the epileptic group were significantly lower (P <0.01), and in the 32 epileptic children, 28 % Had mental retardation; P300 wave ERP latency was also significantly prolonged, P <0.01. Conclusion: Children with epilepsy are prone to mental retardation. The detection of P300 wave latency can evaluate the cognitive function of children with epilepsy at an early stage objectively and accurately.