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目的:探讨咖啡因不同的给药方法治疗早产儿呼吸暂停(AOP)的有效性及安全性。方法:选择2014年6月至2016年9月佛山市妇幼保健院新生儿重症监护病房收治的早产儿共72例,随机分为常规组:负荷量20 mg·kg~(-1)·d~(-1),24 h后维持量每次10 mg·kg~(-1),每日1次;对照组:负荷量20 mg·kg~(-1)·d~(-1),24 h后维持量每次5 mg·kg~(-1),每12 h 1次。比较两组患儿用药7 d内呼吸暂停发作次数及不良反应发生率。结果:对照组患儿7 d内呼吸暂停发生次数明显低于常规组,差异有统计学意义(P<0.05)。两组患儿不良反应比较差异无统计学意义(P>0.05)。结论:咖啡因治疗AOP,每次5 mg,每12 h 1次维持比10 mg·d~(-1)效果更佳,且不会增加不良反应。
Objective: To investigate the efficacy and safety of different administration of caffeine in the treatment of apnea (AOP) in preterm infants. Methods: A total of 72 preterm infants admitted to the Neonatal Intensive Care Unit of Foshan MCH Hospital from June 2014 to September 2016 were randomly divided into the control group (20 mg · kg -1 · d -1) (-1). After 24 h, the maintenance dose was 10 mg · kg -1 every time and the control group was loaded with 20 mg · kg -1 · d -1 h after the maintenance dose of 5 mg · kg -1 every 12 h 1 time. The number of apnea episodes and the incidence of adverse reactions in the two groups were compared within 7 days. Results: The incidence of apnea in control group was significantly lower than that in routine group within 7 days (P <0.05). Adverse reactions between the two groups showed no significant difference (P> 0.05). CONCLUSION: AOP of caffeine is better than 10 mg · d -1 every 5 mg once every 12 h, and it does not increase adverse reactions.