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氯喹能治疗皮肤迟发性卟啉症,一些作者并曾对其作用机理进行了研究。本文报告用卟啉原—六氯苯(HCB)处理小鼠,诱发实验性卟啉症,并同时用氯哇和HCB来处理另一组小鼠,以观察氯喹对卟啉代谢的影响。实验证实:HCB诱发的卟啉症尿中,卟啉和卟啉前体(δ-氨基乙酰丙酸和卟吩色素原)排泄增加,而同时应用氯喹,尿中卟啉前体的排泄则能减到正常水平。卟啉排泄与HCB组相比亦有明显降低。动物肝内的δ-氨基乙酰丙酸盐合
Chloroquine can treat skin delayed porphyria, and some authors have studied its mechanism of action. This article reports the treatment of mice with porphyrinogen - hexachlorobenzene (HCB) to induce experimental porphyria, while another group of mice were treated with chloranil and HCB to observe the effects of chloroquine on the metabolism of porphyrin. Experiments show that: HCB-induced porphyria urine, porphyrin and porphyrin precursor (δ-aminolevulinic acid and porphorin) excretion increased, while the application of chloroquine, urinary porphyrin precursor excretion can Reduced to normal level. Porphyrin excretion and HCB group also significantly reduced. Δ-Aminolevulinic acid in animal liver