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为保证中、晚期肝癌的非手术疗法——肝动脉灌注~(131)I-碘化油的安全性,用~(131)I-标记碘化油给与4只犬进行动脉灌注以观察体内分布、代谢。肝脏分布为74.38应～91.36％,经微循环达双肺仅为2.45～8.57％。~(131)I-碘化油在肝、肺的有效半衰期分别为4.35±0.62天和5.23±0.88天。主要由肾脏排出,每天排泄量相对恒定,为注入剂量的2.6～5.7％。由粪便排泄的活性甚微,每天排泄仅为注入剂量的0.01％左右。结果表明~(131)I-碘化油肝动脉灌注治疗中、晚期肝癌不会造成肝外器官损伤。
In order to ensure the safety of hepatic arterial infusion of 131I-iodinated oil in non-surgical treatment of middle and late stage liver cancer, 4 dogs were perfused with 131I-labeled iodized oil to observe the body. Distribution, metabolism. The distribution of liver is 74.38 should be ~ 91.36%, by microcirculation of lungs only 2.45 ~ 8.57%. The effective half-lives of ~(131)I-iodinated oil in the liver and lung were 4.35±0.62 days and 5.23±0.88 days, respectively. Mainly excreted by the kidneys, the daily excretion is relatively constant, for the injection dose of 2.6 to 5.7%. The activity excreted by the feces is minimal, and the daily excretion is only about 0.01% of the injected dose. The results showed that 131I-iodinated oil hepatic arterial infusion treatment of middle and late stage liver cancer did not cause extrahepatic organ injury.