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研究表柔比星 (epirubicin ,EPI)、顺铂 (csiplatin ,DDP)介入治疗妇科中晚期恶性肿瘤的应用方法及疗效。方法 :44例患者 ,其中宫颈癌 2 9例 ,卵巢癌 1 5例。宫颈癌巨瘤型瘤体直径 4— 6cm ,平均直径 4 8cm。按FIGO分期 :Ⅱa5例 ,Ⅱb1 2例 ,Ⅲa9例 ,Ⅲb2例 ,Ⅳ 3例 ,鳞状上皮癌 2 6例 ,腺癌 3例 ,卵巢癌Ⅱc2例 ,Ⅲ 1 0例 ,Ⅳ 3例 ,(复发癌 2例 ) ,上皮性癌 1 2例 ,转移性低分化腺癌 ,均以病理切片证实。用EPI DDP介入治疗 74人次 ,同时行髂内动脉栓塞 8例 ,子宫动脉栓塞 2 0例 ,进行疗效评定 ,观察其手术切除率 ,近其疗效及毒副反应。结果 :2 5例宫颈癌及 7例卵巢癌行根治术 ;3例卵巢癌仅能行子宫次切除 ,双侧附件切除、阑尾及大网膜切除 ;2例双侧附件切除。症状缓解率 95 4% ( 42 44) ,肿块消退有效率 77 2 % ,手术切除率 84 1 % ( 37 44)。随访 42例 ,失访 2例 ,健在 39例 ,存活期 6— 31月 ,平均 2 4 5月。结论 :EPI DDP介入治疗妇科中晚期恶性肿瘤疗效显著 ,是当前一种增加手术切除率、提高生存率、而毒副反应轻的较理想方法之一。但卵巢癌介入治疗及手术后必须多渠道化疗巩固
To study the application of epirubicin (EPI) and cisplatin (DDP) in the treatment of advanced gynecologic malignancies. Methods: Forty-four patients, including 29 cases of cervical cancer and 15 cases of ovarian cancer. Cervical cancer tumor type diameter of 4 - 6cm, an average diameter of 48cm. According to FIGO staging: Ⅱ a5 cases, Ⅱ b1 2 cases, Ⅲ a9 cases, Ⅲ b2 cases, Ⅳ 3 cases, squamous cell carcinoma 26 cases, adenocarcinoma 3 cases, ovarian cancer Ⅱ c2 cases, Ⅲ 1 0 cases, Ⅳ 3 cases Cancer in 2 cases), epithelial carcinoma in 12 cases, metastatic poorly differentiated adenocarcinoma, confirmed by pathological sections. With EPI DDP interventional treatment of 74 people, at the same time, internal iliac artery embolization in 8 cases, uterine artery embolization 20 cases, the curative effect was evaluated, the surgical resection rate, its efficacy and side effects were observed. Results: Twenty-five cases of cervical cancer and seven cases of ovarian cancer were treated by radical surgery. Only three cases of ovarian cancer were treated by hysterectomy, bilateral accessory resection, appendectomy and omental resection, and two cases of bilateral accessory resection. The rate of symptom relief was 95.4% (42 44), the effective rate of regurgitation was 77.2%, and the rate of resection was 84.1% (37 44). Follow-up 42 cases, 2 cases were lost, alive in 39 cases, survival of 6-31 months, an average of 24.5 months. Conclusion: The interventional therapy of EPI with DDP has a significant effect on advanced gynecologic malignancies. It is one of the more ideal methods to increase the rate of surgical resection and improve the survival rate, while the side effects are mild. However, after ovarian cancer intervention and surgery must be multi-channel chemotherapy consolidation