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抗生素是一类微生物次级代谢活性产物。目前工业上大都采用发酵法进行生产,或将发酵产物经化学修饰后形成产品。至今从土壤微生物中发现的抗生素已超过7000种,其中成为临床药品的约90余种,年产值达160亿美元,是临床上一类重要药物。 在考虑与选择抗生素药物的测定方法时,需考虑它们的以下几个特点: 1.抗生素产生菌的发酵过程是一个复杂的生物合成过程。有众多的酶参与各级反应。抗生素的多组
Antibiotics are a class of secondary metabolites of microorganisms. At present, most industries use fermentation method to produce, or the fermentation products are chemically modified to form products. So far, more than 7,000 kinds of antibiotics have been discovered from soil microorganisms, of which about 90 kinds have become clinical drugs with an annual output value of 16 billion U.S. dollars. It is a clinically important class of drugs. In considering and selecting antibiotic drug determination methods, consider the following characteristics: 1. Antibiotic-producing bacteria fermentation process is a complex biosynthesis process. There are numerous enzymes involved in all levels of response. Multiple groups of antibiotics