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We studied 30 consecutive patients who underwent coronary stenting with respec t to postprocedure endothelial dysfunction and levels of pre-and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow-mediated independent dilation, had higher concentrations of C-re active protein before percutaneous coronary intervention(12.9±20.2 vs 5.6±13.0 μg/ml, p=0.04) and 24 hours after stenting(18.8±.20.8 vs 11.8±.20.0 μg/ml, p=0.05) than patients without severe abnormities of systemic endothelial functio n. Thus, endothelium-dependent dilation abnormalities were related to the syste mic inflammatory state, whereas en-dothelium-independent dilation abnormalitie s were not related to the inflammatory status of the patient.
We studied 30 consecutive patients who underwent coronary stenting with respec t to postprocedure endothelial dysfunction and levels of pre-and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow-mediated independent dilation, had higher concentrations of C- reactive protein before percutaneous coronary intervention (12.9 ± 20.2 vs 5.6 ± 13.0 μg / ml, p = 0.04) and 24 hours after stenting (18.8 ± .20.8 vs 11.8 ± .20.0 μg / ml, p = 0.05) abnormities of systemic endothelial functio n. Thus, endothelium-dependent dilation abnormalities were related to the syste mic inflammatory state, whereas en-dothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.