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目的观察盐酸舍曲林联合美沙拉秦治疗溃疡性结肠炎(UC)伴抑郁患者的临床疗效。方法选取医院收治的UC伴抑郁患者70例为研究对象,随机分为观察组和对照组,每组各35例。对照组给予美沙拉秦治疗,观察组在对照组基础上联合盐酸舍曲林治疗,比较2组患者的临床治疗效果。结果经治疗,观察组总有效率为91.4%,高于对照组的71.4%(P<0.05);治疗后2组抑郁自评量表(SDS)评分明显下降,2组比较差异有统计学意义(P<0.05);2组不良反应比较,差异无统计学意义(P>0.05)。结果盐酸舍曲林联合美沙拉秦治疗UC伴抑郁患者,疗效显著,不良反应少,值得临床推广应用。
Objective To observe the clinical efficacy of sertraline hydrochloride combined with mesalazine in the treatment of patients with ulcerative colitis (UC) and depression. Methods Seventy patients with UC and depression who were admitted to hospital were selected as study subjects and randomly divided into observation group and control group with 35 cases in each group. The control group was treated with mesalazine, and the observation group was treated with sertraline hydrochloride on the basis of the control group. The clinical effects of the two groups were compared. Results After treatment, the total effective rate in the observation group was 91.4%, which was significantly higher than that in the control group (71.4%, P <0.05). After the treatment, the SDS scores of the two groups decreased significantly, and the differences between the two groups were statistically significant (P <0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Results Sertraline hydrochloride combined with Mesalazine treatment of UC with depression, significant effect, less adverse reactions, it is worth promoting the clinical application.