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目的研究SOX2在结直肠癌组织中的表达及其临床意义。方法采用免疫组化法检测115例结直肠癌组织、35例正常结直肠黏膜组织及75例结直肠腺瘤组织中SOX2蛋白表达,并分析其与临床病理参数的关系。结果 SOX2蛋白在结直肠癌组织中的阳性表达率为53.9%,高于正常结直肠黏膜组织的14.3%,但低于结直肠腺瘤组织的76.0%(P<0.05)。SOX2蛋白在不同淋巴结分期、临床分期以及有无远处转移的表达差异有统计学意义(P<0.05)。结论 SOX2参与结直肠癌的发生、发展过程,检测SOX2表达有望成为结直肠癌预后判断及治疗的新指标。
Objective To study the expression of SOX2 in colorectal cancer and its clinical significance. Methods The expression of SOX2 protein in 115 cases of colorectal cancer, 35 cases of normal colorectal mucosa and 75 cases of colorectal adenoma was detected by immunohistochemistry, and its relationship with clinicopathological parameters was analyzed. Results The positive rate of SOX2 protein in colorectal cancer was 53.9%, which was higher than that in normal colorectal mucosa (14.3%) but lower than that in colorectal adenoma (76.0%, P <0.05). The expression of SOX2 protein in different lymph node staging, clinical stage and with or without distant metastasis had statistical significance (P <0.05). Conclusion SOX2 is involved in the occurrence and development of colorectal cancer and detecting the expression of SOX2 is expected to become a new indicator of prognosis and treatment of colorectal cancer.