【摘 要】
：
The relationship between low levels of serum low-density lipoprotein cholesterol(LDL-C)and subse-quent cognitive decline remains unclear.The present study aimed to evaluate the longitudinal associa-tion between low LDL-C levels and cognition decline in th
【机 构】
：
Heart and Vascular Health Research Center,Peking University Clinical Research Institute,Peking Unive
论文部分内容阅读
The relationship between low levels of serum low-density lipoprotein cholesterol(LDL-C)and subse-quent cognitive decline remains unclear.The present study aimed to evaluate the longitudinal associa-tion between low LDL-C levels and cognition decline in the context of the current aggressive guideline-recommended targets(LDL-C levels less than 55 mg/dL for individuals at very high risk of car-diovascular events,and less than 70 mg/dL for high risk individuals).Data from wave 13(2016)to wave 14(2018)of the Health and Retirement Study(HRS)were utilized.LDL-C concentrations measured at wave 13 were categorized into 5 levels,reflecting currently recommended values for lipid lowering treat-ment.Of 7129 included participants(mean age:69.0±9.9 years,60.3％female),we found that compared to participants with LDL-C levels of 70.0-99.9 mg/dL,those with LDL-C levels of＜55 mg/dL had signifi-cantly slower 2-year decline rates in global cognitive function(0.244 point/year;95％confidence interval(CI):0.065-0.422;P = 0.008),working memory(0.068 point/year;95％CI:0.004-0.133;P = 0.038),and borderline significantly in episodic memory(0.155 point/year;95％CI:-0.004-0.315;P = 0.057).Similarly,significantly slower decline rates were observed in those with LDL-C levels of 55.0-69.9 mg/dL.The present study demonstrated that compared with LDL-C levels 70.0-99.9 mg/dL,low LDL-C levels(＜70 mg/dL,especially＜55 mg/dL)were associated with significantly slower cognitive decline in population-based setting.Future randomized controlled trials are warranted to ascertain the safety and benefit of current aggressive guideline-recommended targets on cognitive function.
其他文献
Human glycerol channel aquaporin 7(AQP7)conducts glycerol release from adipocyte and enters the cells in pancreatic islets,muscles,and kidney tubules,and thus regulates glycerol metabolism in those tissues.Compared with other human aquaglyceroporins,AQP7
Metal foams with hierarchically porous structures are highly desirable in energy applications as active materials or their host substrates.However,conventional preparation methods usually have a quite lim-ited flexibility of adjusting pore size of metal f
Thiazolidinediones(TZDs),such as rosiglitazone(RSG),which activates peroxisome proliferator activated receptor-γ(PPARγ),are a potent class of oral antidiabetic agents with good durability.However,the clin-ical use of TZDs is challenging because of their s
The recent discovery and realizations of higher-order topological insulators enrich the fundamental stud-ies on topological phases.Here,we report three-dimensional(3D)wave-steering capabilities enabled by topological boundary states at three different ord
Topological phases in non-Hermitian systems have become fascinating subjects recently.In this paper,we attempt to classify topological phases in 1D interacting non-Hermitian systems.We begin with the non-Hermitian generalization of the Su-Schrieffer-Heege
Amber from Kachin,Myanmar offers a unique window into mid-Cretaceous ecosystems because it provides large sample sets that span a wide range of taxa preserved in exquisite detail at approximately 99 Ma[1].A fringe benefit of such extensive sam-pling is th
Bat coronavirus (CoV) RaTG13 shares the highest genome sequence identity with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among all known coronaviruses,and also uses human angiotensin converting enzyme 2 (hACE2) for virus entry.Thus,SARS-
The information collected from the human body is fundamental for developing the Internet of Things,and may lead to intelligent and ubiquitous health care,human-computer interface,and even advanced human capabilities.However,this will require electronic de
Acute myocardial infarction(MI),one of the most common cardiovascular emergencies,is a leading cause of morbidity and mortality.Ample evidence has revealed an essential role for inflammasome activation and autophagy in the pathogenesis of acute MI.Tax1-bi
The Ediacaran Shuram excursion (SE) is widely regarded as one of the largest carbon isotope (δ13C) negative excursions in Earth history,with carbonate δ13C values down to ca.-12‰ (VPDB) [1].This event has been reported in Ediacaran strata on a global scal