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核受体是一类在生物体内分布广泛、成员众多的转录因子,参与体内亲脂激素、维生素、脂质和其他细胞内信号的转录过程。核受体与相应的配体及其辅助因子相互作用,调控众多靶基因的表达,在机体的生长发育、新陈代谢、细胞分化及体内许多生理过程中发挥重要作用。为了探讨激素相关核受体及其辅助激活因子与骨质疏松之间的关系,通过检索有关激素核受体、核受体辅助因子的功能与骨质疏松的相关文献并进行综述,阐明了激素相关核受体(ER、AR、ERRα、PPARγ)及其辅助激活因子(SRC-1、SRC-2)在骨骼发育中的重要作用,而核受体辅助激活因子SRC-3、PGC-1α可能参与成骨细胞的增殖和分化过程,但作用机制尚不清楚。因此,深入研究SRC-3、PGC-1α在骨代谢中的作用,将为我们深入了解骨质疏松的发病机制具有重要意义。
Nuclear receptors are a class of transcription factors that are widely distributed in the body and have a large membership. They are involved in the transcription of lipophilic hormones, vitamins, lipids and other intracellular signals. Nuclear receptors interact with their ligands and their cofactors to regulate the expression of many target genes and play an important role in the growth and development, metabolism, cell differentiation and many physiological processes in the body. In order to explore the relationship between hormone-related nuclear receptors and their cofactors and osteoporosis, by reviewing and reviewing the relevant literature on the functions of hormone nuclear receptors and nuclear receptor cofactors and osteoporosis, Related nuclear receptors (ER, AR, ERRα, PPARγ) and their costimulatory molecules (SRC-1, SRC-2) play an important role in bone development, and nuclear receptor-assisted activators SRC-3 and PGC- Participate in the proliferation and differentiation of osteoblasts, but the mechanism of action is not yet clear. Therefore, in-depth study of the role of SRC-3 and PGC-1α in bone metabolism will be of great significance for us to understand the pathogenesis of osteoporosis.