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以动脉粥样硬化为病理基础的脑梗死是最常见的脑血管疾病 ,其发病机制与多种因素有关 ,其中遗传因素的作用不可忽视。位于 19号染色体长臂的载脂蛋白E(apoE)基因参与体内的脂质代谢 ,是动脉粥样硬化的易感基因之一 ,其编码产物apoE在神经细胞突触形成及修复过程中起关键作用。a
Atherosclerosis as the basis of cerebral infarction is the most common cerebrovascular disease, its pathogenesis and a variety of factors, including the role of genetic factors can not be ignored. The apolipoprotein E (apoE) gene located on the long arm of chromosome 19 is involved in the lipid metabolism in the body and is one of the susceptible genes of atherosclerosis. The gene encoding apoE plays a key role in synaptic formation and repair of neurons effect. a