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目的:了解临床患者降钙素原(PCT)检测情况,研究PCT检测在指导抗菌药物使用中的临床现状。方法:以治疗性使用抗菌药物出院的患者为研究对象,分析其科室分布、抗菌药物使用率、抗菌药物使用前PCT送检率;将研究对象中发生下呼吸道感染者分为PCT检测组和非PCT检测组,比较两组之间抗菌药物使用的差异性。结果:2014年出院患者中治疗性抗菌药物使用率为34.59%,抗菌药物使用前PCT送检率9.33%;PCT送检科室主要集中在重症医学科、急诊科和内科;3 652例送检PCT患者中20.35%首次检测数值>0.5 ng/m L;出院患者治疗性使用抗菌药物中发生下呼吸道感染者,PCT检测组与非PCT检测组,抗菌药物使用时限有统计学差异,但PCT检测组抗菌药物使用时限更长。结论:目前临床医生对PCT检测的含义可能仍缺乏充分认识,PCT检测尚未发挥对抗菌药物使用的积极指导价值,应针对该现状加强对临床医生相关知识和指南的培训。
OBJECTIVE: To understand the detection of procalcitonin (PCT) in clinical patients and to study the clinical status of PCT testing in guiding the use of antimicrobial agents. Methods: The patients who were discharged from the therapeutic antibacterials were selected as the research object, and their department distribution, the antibacterial drug use rate and the PCT test rate before the antibacterial drug use were analyzed. The subjects with lower respiratory tract infection were divided into PCT test group PCT test group to compare the differences between the two groups in the use of antimicrobial agents. Results: The rate of use of therapeutic antibiotics in discharged patients was 34.59% in 2014 and 9.33% before the use of antibacterial drugs. The PCT sentinel departments mainly focused on intensive care, emergency department and internal medicine; 3,652 cases were examined for PCT 20.35% of the patients had the first detection value> 0.5 ng / m L; the PCT patients in the PCT group and the non-PCT group had statistically significant differences in duration of antimicrobial treatment when they were treated with antibiotics, Antibiotics use longer. Conclusion: At present, clinicians may still lack a full understanding of the meaning of PCT test. PCT test has not yet played a positive guiding value for the use of antimicrobial drugs. Therefore, it is necessary to train clinicians on relevant knowledge and guidelines.