Dysfunctional stem and progenitor cells impair fracture healing with age

• 作 者: Diane R Wagner Sonali Karnik Z
• 机 构: DepartmentofMechanicalandEnergyEngineering,DepartmentofOrthopaedicSurgery,DepartmentofMedicinalChemi
• 出 处: 世界干细胞杂志:英文版(电子版)
• 发表日期: 2019年6期
• 关键词: Fracture HEALING Aging Bone Angiogenesis MESENCHYMAL STEM CELLS Endothelial PROG
• 基金项目: Indiana University Collaborative Research Grant,Indiana Clinical and Translational Sciences Institute, No. NIH UL1TR001108, No. NIH R01 AR069657, No. NIH R01 AR060863 and No. NIH R01 AG060621,This mat

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blo