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AGR2(anterior gradient-2)是一种分泌蛋白,广泛存在于前列腺、乳腺、肺和胰腺等腺体组织,并在这些腺体的肿瘤组织过量表达,与肿瘤细胞的存活、生长和转移相关。临床上,AGR2的表达与乳腺癌、前列腺癌、胰腺癌等癌症的发展和预后相关,被认为是一个很有前途的早期诊断和判定预后的标志性基因。该文就目前AGR2的研究现状,尤其是肿瘤相关的功能、机制和临床调查上的最新研究进展加以综述。
AGR2 (anterior gradient-2) is a secreted protein that is widely found in glandular tissues such as prostate, breast, lung and pancreas and is overexpressed in the tumor tissues of these glands and is associated with the survival, growth and metastasis of tumor cells. Clinically, the expression of AGR2 is associated with the development and prognosis of cancer such as breast cancer, prostate cancer and pancreatic cancer, and is considered as a promising marker for early diagnosis and prognosis. This review summarizes the current state of research on AGR2, especially the latest research on tumor related functions, mechanisms and clinical investigations.