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目的:探讨地中海贫血筛查中,红细胞平均体积(MCV)、平均红细胞血红蛋白含量(MCH)、血红蛋白(HGB)等3项指标的临床价值,为疾病诊治提供科学的指导依据。方法:随机抽2016年2月至2016年6月贵州省黔南州中医医院收录筛查的240例地中海贫血患者资料,均为妇产科受检孕妇;采用分组法讨论,分为观察组与对照组2种检测方法;对照组为“MCV+MCH”检测,观察组为“MCV+MCH+HGB电泳”检测;综合对比单项测试、联合测试2种方法在地中海贫血筛查中的作用,从灵敏度、特异度等指标进行评价,确定单项检测与联合检测结果是否存在差异性。结果:240例患者中,实际结果:α地贫88例,占36.7%;β地贫144例,占60%,αβ复合型地贫8例,占3.3%;观察组:α地贫87例,占36.2%;β地贫141例,占58.8%,αβ复合型地贫7例,占2.9%;灵敏度(97.2%)、特异度(90.6%);对照组:α地贫78例,占32.5%;β地贫132例,占55%,αβ复合型地贫4例,占1.7%;灵敏度(92.4%)、特异度(76.3%)。结论:本次研究说明,观察组检测准确率高于对照组,灵敏度、特异性等均优于对照组,差异具有统计学意义(P<0.05);地中海贫血筛查中采用联合检测方式,具有操作简单、数据精准、可靠度高等特点,可及时检测出地中海贫血病症,减少地贫患儿的出生率,以免对母婴健康造成不利影响。
Objective: To investigate the clinical value of three indicators of thalassemia screening including mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and hemoglobin (HGB), so as to provide scientific guidance for disease diagnosis and treatment. Methods: The data of 240 cases of thalassemia collected from Qiannan State Hospital of Traditional Chinese Medicine from February 2016 to June 2016 were collected from obstetrics and gynecology patients. The patients were divided into observation group and control group Control group 2 test methods; the control group was “MCV + MCH” test, the observation group was “MCV + MCH + HGB electrophoresis” test; comprehensive comparison of single test, combined test of two methods in thalassemia screening The role of sensitivity and specificity of indicators such as evaluation to determine the single test and the joint test results are there any differences. RESULTS: Of the 240 patients, 88 were α thalassemia (36.7%), 144 were β-thalassemia (60%), 8 were αβ-thalassemia (3.3%), and 87 were α-thalassemia , Accounting for 36.2%; 141 cases of β-thalassemia, accounting for 58.8%, 7 cases of αβ-thalassemia complex, accounting for 2.9%; the sensitivity was 97.2% and the specificity was 90.6% 32.5%; β thalassemia in 132 cases, accounting for 55%, αβ polysemy in 4 cases, accounting for 1.7%; sensitivity (92.4%), specificity (76.3%). Conclusion: This study shows that the detection accuracy of the observation group is higher than that of the control group, the sensitivity and specificity are better than the control group, the difference was statistically significant (P <0.05); the detection of thalassemia using joint detection, with Simple operation, accurate data and high reliability, it can timely detect the thalassemia symptoms and reduce the birth rate of children with thalassemia, so as to avoid adverse effects on the health of mothers and children.