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目的提高胸腺瘤合并重症肌无力的外科治疗水平。方法对28例经过手术治疗的胸腺瘤合并重症肌无力患者的临床资料及随访资料进行分析。结果全组无围术期死亡。术后5例患者发生重症肌无力危象,经延长呼吸机辅助通气治疗安全度过围术期。出院后进行定期随访,随访时间6个月至6年。完全缓解12例,改善8例,无效5例,死亡3例。结论合理选择病例、彻底手术切除、完善围术期管理、减少肌无力危象的发生,外科治疗胸腺瘤合并重症肌无力可获得良好的疗效。
Objective To improve the surgical treatment of thymoma with myasthenia gravis. Methods The clinical data and follow-up data of 28 patients with thymoma complicated with myasthenia gravis surgically treated were analyzed. Results There was no perioperative death in the whole group. Postoperative five patients with myasthenia gravis crisis, prolonged ventilator assisted ventilation over perioperative period. After discharge regular follow-up, follow-up time of 6 months to 6 years. Complete remission in 12 cases, improvement in 8 cases, 5 cases, 3 cases died. Conclusion The reasonable choice of cases, complete surgical resection, perioperative management and perinatal management to reduce the risk of myasthenia gravis crisis, surgical treatment of thymoma with myasthenia gravis can obtain a good effect.