论文部分内容阅读
目的观察脑局部亚低温治疗对急性脑梗死患者血清中神经元特异性烯醇化酶(NSE)、S-100蛋白浓度的影响和临床疗效,探讨其对脑缺血的保护机制。方法随机将66例急性脑梗死患者分为治疗组和对照组各33例,治疗组在药物治疗脑梗死的同时加用局部亚低温治疗技术,在发病后1、3、7、14 d进行NSE、S-100蛋白含量的测定,在治疗前和治疗后7、14、30 d根据《美国国立卫生研究所脑卒中量表》(NIHSS)进行神经功能缺损评分。结果与对照组比较,治疗组治疗14、30 d后神经功能缺损评分降低(P<0.01),发病后3、7、14 d血清NSE含量明显降低(P<0.01),治疗7、14 d S-100蛋白含量降低(P<0.05)。结论局部亚低温治疗技术对神经细胞有较好的保护作用,可改善急性脑梗死患者神经功能缺损及预后。
Objective To observe the effect of local mild hypothermia on serum levels of neuron specific enolase (NSE) and S-100 protein in patients with acute cerebral infarction and its clinical efficacy, and to explore its protective mechanism on cerebral ischemia. Methods A total of 66 patients with acute cerebral infarction were randomly divided into treatment group (33 cases) and control group (33 cases). In the treatment group, local mild hypothermia was used in the treatment of cerebral infarction. NSE , S-100 protein content, neurological deficit scores were assessed according to NIH Stroke Scale (NIHSS) before treatment and at 7, 14 and 30 days after treatment. Results Compared with the control group, the neurological deficit score of the treatment group decreased after 14 and 30 days of treatment (P <0.01), and the serum NSE level decreased significantly on the 3rd, 7th and 14th days after the onset of treatment (P <0.01) -100 protein content decreased (P <0.05). Conclusion Local mild hypothermia therapy has a good protective effect on nerve cells, can improve neurological deficits and prognosis in patients with acute cerebral infarction.