抗菌肽的临床应用与内源性表达调控研究进展

• 作 者: 陈红伟 李英伦 刘娟 吴俊伟 黄庆洲
• 机 构: 西南大学动物医学系,四川农业大学动物医学院,
• 出 处: 生物技术通报
• 发表日期: 2014年04期
• 关键词: 抗菌肽 Ⅲ期临床试验 基因表达调控 开发 策略

抗菌肽是具有抗菌活性的一类短肽,具有分子量低、热稳定、广谱的抗菌、抗病毒及抑制肿瘤的生物活性,是动植物防御体系的一个重要组成部分,在机体抵抗病原的入侵方面起着重要的作用。但实践表明,作为抗生素替代品的抗菌肽的开发并非易事。针对近年来抗菌肽研究的热点,对抗菌肽的临床应用和表达调控进行了简要综述。

Antibacterial peptides are a kind of short peptides with antibacterial activity. They are low molecular weight, thermostable, broad-spectrum antibacterial, antiviral and tumor inhibiting biological activity. They are an important part of plant and animal defense system. Aspects play an important role. However, practice shows that the development of antimicrobial peptides as antibiotic substitutes is not easy. In view of the hotspot of antimicrobial peptides in recent years, the clinical application and expression regulation of antimicrobial peptides are briefly reviewed.