论文部分内容阅读
目的观察地尔硫缓释剂对高血压合并冠心病患者疗效。方法２９例高血压合并冠心病患者口服地尔硫缓释剂９０ｍｇ，２／ｄ，用药４周，应用２４ｈ动态血压和动态心电图观察用药前后血压和缺血性ＳＴ段的变化。结果用药后２４ｈ收缩压（ＳＢＰ）从１４５±９降至１２７±１２ｍｍＨｇ，舒张压（ＤＢＰ）从１０６±１１降至８２±１５ｍｍＨｇ（Ｐ＜０．０５）；ＳＢＰ负荷由６４±９％降至３８±９％（Ｐ＜０．０１），ＤＢＰ负荷由５４±１４％降至２９±１０％（Ｐ＜０．０１）。心肌缺血发作频率从４．３±２．０降至２．３±１．０／２４ｈ，缺血总时间（ｍｉｎ／２４ｈ）从１６．９±３．９降至９．４±２．９，最大ＳＴ段下移由１．４±０．５ｍｍ降为０．８±０．３ｍｍ（Ｐ＜０．０１）。结论地尔硫缓释剂能显著改善高血压合并冠心病患者的心肌缺血和降低患者血压。
Objective To observe the efficacy of diltiazem in relieving hypertensive patients with coronary heart disease. Methods Twenty-nine patients with hypertension and coronary heart disease were treated with sustained-release diltiazem 90mg, 2 / d for 4 weeks. The changes of blood pressure and ischemic ST segment before and after treatment were observed by 24h ambulatory blood pressure and ambulatory electrocardiogram. Results SBP decreased from 145 ± 9 to 127 ± 12 mmHg and diastolic blood pressure (DBP) decreased from 106 ± 11 to 82 ± 15 mmHg (P <0.05) at 24h after treatment. The SBP load decreased from 64 ± 9% 38 ± 9% (P <0.01), DBP load decreased from 54 ± 14% to 29 ± 10% (P <0.01). The frequency of myocardial ischemic attack decreased from 4.3 ± 2.0 to 2.3 ± 1.0 / 24h, and the total ischemic time (min / 24h) decreased from 16.9 ± 3.9 to 9.4 ± 2. 9, the maximum ST segment down from 1.4 ± 0.5mm down to 0.8 ± 0.3mm (P <0.01). Conclusion Diltiazem can relieve myocardial ischemia and decrease blood pressure in hypertensive patients with coronary heart disease.