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环孢菌素A(CyA)是由真菌(Trichoderma poly-sporium和Cylindrocarpon lucidum)产生的一种多肽,具有免疫抑制的活性。本文报道经异体肾移植手术的兔实验中使用CyA作为免疫抑制药的实验结果。实验使用不同种系的新西兰和非新西兰白兔,共分三组。第一组用兔22只,进行两侧肾切除,移植一侧异体肾。移植术后,每天肌内注射25mg/kg的CyA;第二组兔
Cyclosporine A (CyA) is a polypeptide produced by fungi (Trichoderma poly-sporium and Cylindrocarpon lucidum) with immunosuppressive activity. This article reports the experimental results of using CyA as an immunosuppressive drug in rabbit experiments of allograft kidney transplantation. Experiments using different strains of New Zealand and non-New Zealand white rabbits, divided into three groups. The first group of 22 rabbits, bilateral nephrectomy, allogeneic kidney transplantation. After transplantation, CyA was injected intramuscularly at 25 mg / kg daily; the second group of rabbits