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探讨血清酸性异铁蛋白和铁蛋白含量变化在诊断肺癌中的临床价值。方法用放射免疫法（ＲＩＡ）检测４３例老年肺癌，２８例老年肺结核患者的血清酸性异铁蛋白（ＡＩＦ）和铁蛋白（Ｆｅｒ）含量。结果其值分别为２６２．４±１２４．２ｍｇ／Ｌ和１６０．４±７４．２ｍｇ／Ｌ；１４１．８±８２．５ｍｇ／Ｌ和１０２．２±５８．２ｍｇ／Ｌ。同时检测３０例健康人作为对照，其正常值为１０２．６±５３．４ｍｇ／Ｌ和７１．２±３８．４ｍｇ／Ｌ。老年肺癌的ＡＩＦ、Ｆｅｒ含量均显著高于对照组（Ｐ＜０．０１），较老年肺结核组也有显著增高（Ｐ＜０．０１）。结论推荐血清ＡＩＦ、Ｆｅｒ含量作为肺癌特异性诊断的两个血清学指标。
To explore the clinical value of serum acid isoferritin and ferritin changes in the diagnosis of lung cancer. Methods Radioimmunoassay (RIA) was used to detect the serum levels of acidic isoferritin (AIF) and ferritin (Fer) in 43 elderly patients with lung cancer and 28 elderly patients with pulmonary tuberculosis. The results were 262.4±124.2 mg/L and 160.4±74.2 mg/L; 141.8±82.5 mg/L and 102.2±58.2 mg/L, respectively. At the same time, 30 healthy people were tested as controls. The normal values were 102.6±53.4 mg/L and 71.2±38.4 mg/L. The content of AIF and Fer in lung cancer in elderly patients was significantly higher than that in the control group (P<0.01), and it was also significantly higher in elderly patients with pulmonary tuberculosis (P<0.01). Conclusion Serum AIF and Fer are recommended as two serological markers for the specific diagnosis of lung cancer.