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目的观察单纯疱疹病毒性角膜炎（ｈｅｒｐｅｓｓｉｍｐｌｅｘｋｅｒａｔｉｔｉｓ，ＨＳＫ）局部角膜免疫反应与其发病的关系。方法用ＨＥ染色及ＬＳＡＢ法染色对２１例ＨＳＫ病例角膜进行组织病理及免疫组化观察。结果组织病理显示ＨＳＫ活动期以多形核白细胞为主，少量单核样细胞。静止期以单核样细胞为主。免疫组化显示ＣＤ４、ＣＤ８、ＣＤ１４、ＣＤ１５、ＣＤ２０、ＣＤ６８、ＣＤ７１、ＨＬＡ－ＤＲ、ＨＳＶ－１、ＨＳＶ－２阳性率分别为１５．８％、１５．８％、４７．１％、２１．１％、２１．１％、８８．９％、５０％、６６．７％、７２．７％、６３．６％。结论提示体液免疫及细胞免疫均参与了ＨＳＫ的发病过程，细胞免疫在ＨＳＫ的发病中起十分重要作用。
Objective To observe the relationship between the local corneal immune response and the pathogenesis of herpes simplex keratitis (HSK). Methods HE staining and LSAB staining were used to observe the histopathology and immunohistochemistry of 21 cases of HSK. Results Histopathology showed that polymorphonuclear leukocytes were predominant in HSK and a few mononuclear cells. Quiescent monocyte-like cells. Immunohistochemistry showed that the positive rates of CD4, CD8, CD14, CD15, CD20, CD68, CD71, HLA-DR, HSV-1 and HSV-2 were 15.8%, 15.8% and 47.1%, respectively. 1%, 21.1%, 88.9%, 50%, 66.7%, 72.7%, 63.6%. Conclusions suggest that both humoral immunity and cellular immunity are involved in the pathogenesis of HSK. Cellular immunity plays a very important role in the pathogenesis of HSK.