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目的:观察复方甘草酸苷(美能)治疗化疗药导致肝损害的疗效。方法:将45例由于化疗导致肝功能损害的患者随机分成治疗组(24例)和对照组(21例),治疗组在对照组用药基础上加用复方甘草酸苷。结果:治疗组在丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素的改善程度上均明显优于对照组(P<0.01)。结论:复方甘草酸苷对化疗引起的药物性肝功能损害有很好的治疗作用,不良反应少,用药安全。
Objective: To observe the curative effect of compound glycyrrhizin (Mei Neng) in treating chemotherapy-induced liver damage. Methods: Forty-five patients with liver dysfunction induced by chemotherapy were randomly divided into treatment group (24 cases) and control group (21 cases). The treatment group was given compound glycyrrhizin on the basis of the control group. Results: The improvement of alanine aminotransferase, aspartate aminotransferase and total bilirubin in the treatment group was significantly better than that in the control group (P <0.01). Conclusion: Compound glycyrrhizin has a good therapeutic effect on chemotherapy-induced liver dysfunction with less adverse reactions and safe administration.