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脑卒中后抑郁（ PSD）是脑卒中后常见的神经精神并发症。其发病机制尚未完全明确，涉及脑卒中后的神经生物学改变和心理应激障碍，而且相关因素复杂，研究表明PSD与高血清胆红素、血清糖化血红蛋白水平低及痴呆评定量表评分减低、血糖水平升高、维生素 B12缺乏、低水平的高密度脂蛋白相关，患者的临床表现及诊断缺乏特异性，在治疗方面，以药物治疗为主，辅以心理治疗等其他治疗方法。目前对于PSD的相关问题尚需进一步研究。“,”Post-stroke depression(PSD) is a common neuropsychiatric complication after stroke.The pathogenesis is not fully clear yet,which involves the neuronal biological factors and psychological stress dis-orders after stroke,and the related factors are complex.Recent studies have shown that PSD is associated with high serum total bilirubin,low serum levels of glycosylated hemoglobin and lower MDRS I/P scores,high ser-um levels of glucose,vitamin B12 deficiency and low levels of HLD.The clinical manifestations and diagnosis are lack of specificity.As for the treatment, drug treatment is the major method,supplemented by other treat-ments such as psychotherapy.Further study is still needed for the PSD related problems.