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通常认为矽肺发病的重要环节之一是肺泡巨噬细胞吞噬二氧化硅(SiO_2)粉尘颗粒后的崩解死亡。因此,凡能保护巨噬细胞的药物就可能具有防治矽肺的作用。柠檬酸铝(柠铝)对实验性动物矽肺以及临床矽肺病人的疗效可能正是与其体外保护巨噬细胞的作用有关。最近体外研究证明,SiO_
One of the most important aspects of silicosis is thought to be the disintegration of alveolar macrophages after phagocytosis of silica particles. Therefore, any drug that protects macrophages may have the effect of preventing and treating silicosis. Therapeutic effects of aluminum citrate (ALA) on experimental animal silicosis and clinical silicosis may be related to its role in protecting macrophages in vitro. Recent in vitro studies have shown that SiO_