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目的探讨氯吡格雷、丁苯酞注射液早期联合给药对脑梗死的治疗效果。方法选择舞钢市人民医院2015年3月至2016年5月期间收治的102例脑梗死患者为研究对象,随机分为观察组(51例)与对照组(51例)。对照组患者给予氯吡格雷治疗,观察组患者给予氯吡格雷联合丁苯酞注射液进行治疗。比较两组患者治疗前及治疗后第7、14d神经功能评分、治疗前后血液黏度变化及临床疗效。结果治疗前两组神经功能评分、血浆黏度(PSV)及血高切黏度(HSV)水平相比,差异无统计学意义(P>0.05);治疗后两组患者神经功能评分均有所下降,观察组患者下降趋势优于对照组,差异有统计学意义(P<0.05);治疗后两组患者PSV、HSV水平均有所改善,观察组优于对照组,差异有统计学意义(P<0.05);治疗后观察组患者的临床疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论脑梗死患者给予氯吡格雷、丁苯酞注射液早期联合给药治疗可有效改善患者的神经功能损坏现象,调节血液黏度,提高治疗效果,临床应用价值高。
Objective To investigate the therapeutic effect of clopidogrel and butylphthalide injection on cerebral infarction. Methods A total of 102 patients with cerebral infarction admitted from March 2015 to May 2016 in Wugang People’s Hospital were randomly divided into observation group (51 cases) and control group (51 cases). Patients in the control group were treated with clopidogrel, and patients in the observation group were treated with clopidogrel combined with butylphthalide. The neurological scores, the changes of blood viscosity before and after treatment, and the clinical curative effect were compared between the two groups before treatment and 7 and 14 days after treatment. Results There was no significant difference in neurological function score, plasma viscosity (PSV) and HSV before treatment between two groups (P> 0.05). After treatment, the scores of neurological function decreased in both groups, The decline trend of observation group was better than that of control group, the difference was statistically significant (P <0.05). After treatment, PSV and HSV levels were improved in both groups, the observation group was better than the control group, the difference was statistically significant (P < 0.05). After treatment, the total effective rate of clinical treatment in observation group was higher than that in control group (P <0.05). Conclusion Clopidogrel given in patients with cerebral infarction, butylphthalide injection early combination therapy can effectively improve patients with neurological damage, regulate blood viscosity and improve the therapeutic effect, clinical application of high value.