使用阴道避孕环与口服避孕药后的子宫内炔雌醇与依托孕烯浓度比较

• 作 者: Roumen F.J.M.E. Dieben T.O.M. 李跃萍
• 机 构: NV Organon Clinical Development Department P.O. Box 20 Oss 5340 BH Netherlands Dr,
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年04期
• 关键词: 阴道避孕环 口服避孕药 炔雌醇 子宫 浓度 绝经前女性 子宫组织 子宫内膜 子宫切除手术 子宫切除术

Objective: To compare uterine tissue concentrations of ethinyl estradiol (EE) and etonogestrel (ENG) after one cycle of use of a contraceptive vaginal ring (NuvaRing;NV Organon, Oss, The Netherlands) or a combined oral contraceptive (COC). Design: Randomized, open-label, pharmacokinetic study. Setting: Obstetrics and gynecology unit. Patient(s): Eight premenopausal women about to undergo hysterectomy but otherwise healthy. Intervention(s): One cycle (17-21 days) of NuvaRing or COC treatment that ended with surgical hysterectomy. Main Outcome Measure(s): Tissue concentrations of EE and ENG in uterine tissue samples taken from the upper myometrium and mid-myometrium, the cervical region, and the endometrium. Result(s): In both groups, concentrations of EE and ENG were similar in uterine tissue taken from the upper myometrium and mid-myometrium and the cervical region. However, compared with the COC group, concentrations of both hormones were markedly lower in tissue samples from the endometrium of women who had been treated with NuvaRing. Conclusion(s): Vaginal administration of hormones with NuvaRing did not produce elevated uterine concentrations of EE and ENG, compared with an oral contraceptive.

Objective: To compare uterine tissue concentrations of ethinyl estradiol (EE) and etonogestrel (ENG) after one cycle of use of a contraceptive vaginal ring (NuvaRing; NV Organon, Oss, The Netherlands) or a combined oral contraceptive Patient (s): Eight premenopausal women about to undergo hysterectomy but otherwise healthy. Intervention (s): One cycle (17-21 days) of NuvaRing or COC treatment That ended with surgical hysterectomy. Main Outcome Measure (s): Tissue concentrations of EE and ENG in uterine tissue samples taken from the upper myometrium and mid-myometrium, the cervical region, and the endometrium. Results (s): In both groups, concentrations of EE and ENG were similar in uterine tissue taken from the upper myometrium and mid-myometrium and the cervical region. However, compared with the COC group, concentrations of both hormones were markedly lower in tissue samples from the endo Conclusion (s): Vaginal administration of hormones with NuvaRing did not produce elevated uterine concentrations of EE and ENG, compared with an oral contraceptive.