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目的评价连续电除颤与单次电除颤在长时程心室颤动(室颤)中的抢救效果。方法将24只犬采用体外电击法制备室颤动物模型,室颤维持8 min后,将动物随机分为连续电除颤组和单次电除颤组。连续或单次电除颤后立即进行2min心肺复苏,循环以上抢救步骤,直至动物复苏成功或抢救时间超过15min。记录两组动物的复苏延搁时间、复苏成功率、复苏后血流动力学参数以及左室射血分数。结果与连续电除颤组相比,单次电除颤组在整个心肺复苏过程中的复苏延搁时间明显减少(P<0.05),复苏成功率明显提高(P<0.05),复苏后的冠脉灌注压和射血分数均较高(P均<0.05)。结论对于长时程室颤的抢救,单次电除颤的效果明显优于连续电除颤。
Objective To evaluate the efficacy of continuous defibrillation and single defibrillation in long-term ventricular fibrillation (VF). Methods Twenty-four dogs were prepared by electric shock in vitro. After ventricular fibrillation was maintained for 8 min, animals were randomly divided into continuous defibrillation group and single defibrillation group. Continuous or single defibrillation immediately after 2min cardiopulmonary resuscitation, cycle above the rescue steps, until the successful resuscitation or rescue of animals more than 15min. Delayed resuscitation, resuscitation success rate, hemodynamic parameters after resuscitation and left ventricular ejection fraction were recorded. Results Compared with the continuous defibrillation group, the defibrillation group showed a significant reduction in the delay of resuscitation (P <0.05) and the success rate of resuscitation (P <0.05), while the recovery of coronary artery Perfusion pressure and ejection fraction were higher (P <0.05). Conclusion For the long-term rescue of ventricular fibrillation, the effect of single defibrillation is significantly better than continuous defibrillation.