论文部分内容阅读
报告三例由呋喃唑酮引起的多发性神经炎和精神障碍,并对神经系统中毒症状、临床特点及发病机制略加讨论。例一,女性,38岁。于1976年7月23日至1978年1月5日因反复腹写,断续地投呋喃唑酮,在5个月内投药5次,每次服药4～12天,每天投药0.3～0.6克,共投药32天,总量16.5克,最后一次投药持续12天,每天是0.6克。于1977年1月5日病人自述:“双手没劲,双腿发麻,疼痛难忍,不能走路。”查:体温36.8℃,脉搏80次/分,血压120/80毫米汞柱,神清,瞳孔等元,对光反应佳,眼震(-),颈软,心肺未见阳性体征,腹软,肝脾未及。神经系统检查:双下肢深浅感觉减退,双上肢轻瘫,双下肢完全性瘫痪,下肢肌肉轻度萎缩,肱二、三头肌反射对称减
Three cases of polyneuritis and mental disorders caused by furazolidone were reported and the symptoms, clinical features and pathogenesis of nervous system poisoning were slightly discussed. Example one, female, 38 years old. July 23, 1976 to January 5, 1978 due to repeated abdominal writing, intermittent furazolidone investment in 5 months 5 times, each taking 4 to 12 days, 0.3 to 0.6 grams per day, a total of Dosing 32 days, a total of 16.5 grams, the last dose for 12 days, 0.6 grams per day. On January 5, 1977, the patient readme: “My hands are boring, my legs are tingling, my pain is unbearable and I can not walk.” Check: The temperature is 36.8 ℃, the pulse is 80 beats / min, the blood pressure is 120/80 mm Hg, Pupil and other yuan, good light response, nystagmus (-), neck soft, no positive signs of heart and lung, abdominal soft, liver and spleen not yet. Nervous system examination: both lower extremity feel diminished, upper extremity paresis, complete paralysis of both lower extremities, mild lower extremity muscle atrophy, brachial and triceps reflex symmetry reduction