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目的探讨慢性丙型肝炎患者血清转化生长因子β1(TGF-β1)、白细胞介素-6(IL-6)和白细胞介素-10(IL-10)水平检测的临床意义。方法选取2010年11月至2013年11月所收治的48例慢性丙型肝炎患者为患者组,另外选取我院体检中心经健康体检合格者35例为正常人组,均在清晨空腹抽取3ml静脉血,在抽血1h内对血清进行分离,而后再置于-20℃进行保存待测。结果患者组血清IL-10含量为(38.4±15.4)pg/ml,血清IL-6含量为(11.4±4.6)pg/ml,血清TGF-β1含量为(42.2±26.7)μg/L;而正常人组血清IL-10含量为(21.2±8.2)pg/ml,血清IL-6含量为(5.2±3.1)pg/ml,血清TGF-β1含量为(8.8±3.6)μg/L;二者差异显著,具有统计学意义(P<0.05)。结论慢性丙型肝炎患者血清TGF-β1、IL-6和IL-10水平检测的临床意义较大,对于探讨慢性丙型肝炎患者的发病机制、了解病情具有较为重要的作用,值得临床广泛应用。
Objective To investigate the clinical significance of detecting serum levels of transforming growth factor β1 (TGF-β1), interleukin-6 (IL-6) and interleukin-10 (IL-10) in patients with chronic hepatitis C Methods Forty-eight patients with chronic hepatitis C admitted to our hospital from November 2010 to November 2013 were enrolled. In addition, 35 healthy people who passed the physical examination in our hospital were selected as healthy subjects. All patients were given 3ml intravenous Blood, within 1h after blood serum separation, and then placed at -20 ℃ to be stored for testing. Results Serum IL-10 level was (38.4 ± 15.4) pg / ml, serum IL-6 level was (11.4 ± 4.6) pg / ml and serum TGF-β1 level was (42.2 ± 26.7) Serum levels of IL-10 were (21.2 ± 8.2) pg / ml, serum IL-6 levels were (5.2 ± 3.1) pg / ml and serum TGF- Significantly, statistically significant (P <0.05). Conclusion Serum levels of TGF-β1, IL-6 and IL-10 in patients with chronic hepatitis C are of great clinical significance. It is of great significance to explore the pathogenesis of chronic hepatitis C and to understand the condition of patients with chronic hepatitis C, which is worthy of clinical application.