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目的提高对米勒-费舍尔综合征诊断与治疗的认识。方法回顾分析2007年3月-2012年3月6例米勒-费舍尔综合征的临床资料,结合国内外报道及研究进展,探讨对米勒-费舍尔综合征的再认识。结果 6例米勒-费舍尔综合征患儿中共济失调6例,表现为步态不稳、指鼻不准,甚至不能行走,球麻痹3例,表现为饮水呛咳,声调下降,言语不清,眼肌麻痹6例,表现为眼球运动受限,部分上睑下垂,部分眼球震颤,腱反射消失6例表现为膝腱反射、跟腱反射消失;头颅CT或MRI正常6例,脑脊液蛋白-细胞分离6例,电生理检查提示周围神经损害6例。结论米勒-费舍尔综合征是格林-巴利综合征的变异型,眼肌麻痹、共济失调、腱反射消失是其主要特点,多伴有脑脊液蛋白-细胞分离和周围神经损害,预后良好。
Objective To raise awareness of the diagnosis and treatment of Miller-Fisher syndrome. Methods The clinical data of 6 patients with Miller-Fischer syndrome from March 2007 to March 2012 were retrospectively analyzed. Based on the reports and research progress both at home and abroad, the re-recognition of Miller-Fischer syndrome was discussed. Results 6 cases of Miller - Fisher syndrome in children with ataxia in 6 cases, manifested as unsteady gait, fingers are not allowed, or even walking, ball paralysis in 3 cases, manifested as cough drinking water, the tone decreased, 6 cases of ophthalmoplegia showed ophthalmoplegia, partial ptosis, partial nystagmus, and disappearance of tendon reflex. Six cases showed knee tendon reflexes and Achilles tendon reflex disappeared. Six cases of normal CT or MRI skull, Cerebrospinal fluid protein-cell separation in 6 cases, electrophysiological examination showed peripheral nerve damage in 6 cases. Conclusion Miller-Fischer syndrome is a variant of Guillain-Barre syndrome. Ophthalmoplegia, ataxia and tendon reflex disappear are the main features, which are associated with cerebrospinal fluid protein-cell separation and peripheral nerve damage. Prognosis good.