论文部分内容阅读
随着中枢神经系统(CNS)白血病预防的推广,不仅减少了 CNS 白血病发生,也进一步改善了儿童急性淋巴细胞白血病(ALL)的生存率。现已发现 ALL长期生存之男孩中,一个新的并发症——睾丸白血病之发病率正在上升。资料和方法:作者报导1971～1975年在辛辛那堤儿童医院医疗中心与依阿华大学附属医院确诊的60例男孩 ALL。各例治法相似:用长春新硷与强的松诱导缓解;继之以头颅放疗及鞘内注射氨甲蝶呤进行 CNS预防;然后用6-巯基嘌呤与氨甲蝶呤维持治疗。持续缓解>30月者,便中止治疗。对那些潜在的长期生存者通过回顾性分析病史以确定有否睾丸或其他部位白血病的复发。1977年后前瞻性地对中止治疗的男孩作睾丸选择性楔形活检。标本用10%甲醛缓冲液固定、石蜡包埋及苏木素-伊红(H.E.)染色。结果:60例 ALL 男孩中,持续缓解>30月者共29
With the promotion of central nervous system (CNS) leukemia prevention, it not only reduces the incidence of CNS leukemia, but also further improves the survival rate of childhood acute lymphoblastic leukemia (ALL). It has been found in ALL long-term survival of boys, a new complication - the incidence of testicular leukemia is on the rise. DATA AND METHODS: The authors reported 60 boys ALL diagnosed at Cincinnati Children’s Hospital Medical Center and University of Iowa Affiliated Hospital from 1971-1975. Each treatment method is similar: with vincristine and prednisone induced remission; followed by cephalic radiotherapy and intrathecal methotrexate for CNS prevention; and then 6-mercaptopurine and methotrexate maintenance treatment. Sustained remission> 30 months, they stopped treatment. Retrospective analysis of the medical history of potential long-term survivors to determine whether there is a testicular or other parts of the recurrence of leukemia. After 1977, a prospective selective testicular wedge biopsy was performed on aborted boys. Specimens were fixed with 10% formaldehyde buffer, embedded in paraffin and stained with H.E. Results: Of the 60 ALL boys, 29 had sustained remission> 30 months