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目的:研究新疆维吾尔族人群环氧化物水解酶(EPHX2)基因rs751141多态性与原发性高血压的关系。方法:通过流行病学调查获得新疆维吾尔族原发性高血压患者302例(高血压组),健康对照组323例,采用TaqMan探针法分析EPHX2基因rs751141多态性的基因型。结果:高血压组与对照组EPHX2基因rs751141G/A多态性差异无统计学意义。结论:EPHX2基因rs751141G/A多态性与新疆维吾尔族原发性高血压无相关性。
Objective: To study the relationship between polymorphism of epoxide hydrolase (EPHX2) rs751141 and essential hypertension in Xinjiang Uygur population. Methods: 302 cases of hypertension (hypertension group) and 323 healthy controls were collected from epidemiological investigation in Uighur Xinjiang. The genotypes of rs751141 polymorphism of EPHX2 gene were analyzed by TaqMan probe. Results: There was no significant difference in rs751141G / A polymorphism of EPHX2 gene between hypertensive group and control group. Conclusion: There is no correlation between rs751141G / A polymorphism of EPHX2 gene and essential hypertension in Uighur in Xinjiang.