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目的揭示过敏性紫癜(HSP)是免疫介导性疾病,早期即存在肾损害。方法随机选取20例健康者作为对照组,急性期(发病时间在二周以内)HSP患者57例,并分为A、B两组,非紫癜性肾炎者为A组,紫癜性肾炎为B组。比较两组的血清免疫球蛋白IgA、IgG、补体C3和尿微量白蛋白(MA)、尿α1微球蛋白(α1-M)蛋白情况。结果HSP的尿MA、α1-M均较正常组增高(P<0.01),有极显著性差别;HSP血清IgA、C3,与正常对照组比较(P>0.05),无显著性差别;A、B两组血清IgG,与对照组比较(P<0.05),有显著性差别,IgG水平明显降低。结论尿微量蛋白的检测应作为HSP的常规检查项目;IgA和IgG在肾脏的沉积增加,是造成HSP肾损伤的主要原因。
Objective To reveal that Henoch-Schonlein Purpura (HSP) is an immune-mediated disease with early renal impairment. Methods Twenty healthy subjects were selected randomly as the control group. Fifty-seven acute HSP patients (onset time less than two weeks) were divided into A and B groups, group A was non-purpura nephritis and group B was purpura nephritis . Serum immunoglobulin IgA, IgG, complement C3, urinary microalbumin (MA) and urinary α1-microglobulin (α1-M) protein were compared between the two groups. Results Compared with the normal group, the urinary MA and α1-M levels in HSP increased significantly (P <0.01), and there was a significant difference between the two groups. The levels of IgA and C3 in HSP were not significantly different from those in the normal control group (P> 0.05) B serum IgG, compared with the control group (P <0.05), there was a significant difference, IgG levels were significantly lower. Conclusion The detection of urinary microalbumin should be used as routine examination of HSP. The deposition of IgA and IgG in the kidney is the main cause of HSP renal injury.