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目的:研究丹参酚酮片中丹参酮IIA在大鼠肠中吸收情况。方法:采用大鼠原位肠吸收模型,以HPLC法测定肠中丹参酮IIA的变化量,探索其体内吸收与体外溶出的相关性。结果:丹参酚酮片中丹参酮IIA在大鼠在体肠循环灌流过程中丹参酮ⅡA迅速减少,由于大鼠离体胃、肠体外温孵试验中均对丹参酮ⅡA未见有吸附、摄取或代谢,故可认为丹参酮ⅡA于肠循环液中的消失可基本代表其吸收情况。结论:在体肠循环液中丹参酮ⅡA消失情况代表着丹参酮ⅡA肠的吸收,以1、2、4片中丹参酮ⅡA小剂量吸收量为59.52%、73.83%和86.49%,中剂量为42.19%、66.40%和78.09%;大剂量为35.00%、58.04%和74.25%。
Objective: To study the absorption of tanshinone IIA in rat intestine in Salvia miltiorrhiza tablets. Methods: The rat model of intestinal absorption in situ was used to determine the change of tanshinone IIA in the intestine by HPLC, and to explore the correlation between absorption in vivo and dissolution in vitro. Results: Tanshinone IIA in Salviae Miltiorrhizae tablets rapidly decreased in rats during intestinal perfused perfusion. Since there was no adsorption, uptake or metabolism of tanshinone IIA in the isolated rat stomach and intestine in vitro, It can be concluded that the disappearance of tanshinone Ⅱ A in the intestinal fluid can basically represent the absorption of its situation. Conclusion: The disappearance of tanshinone ⅡA in the intestinal fluid shows the intestinal absorption of tanshinone ⅡA. The absorption of small dose of tanshinone ⅡA in 1, 2 and 4 tablets is 59.52%, 73.83% and 86.49%, and the middle dose is 42.19% 66.40% and 78.09%; high dose of 35.00%, 58.04% and 74.25%.