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目的 :观察老年慢性乙型肝炎的临床特点及血栓通对其治疗作用 ,探讨血栓通抗肝纤维化的作用机理。方法 :观察 63例老年慢性乙型肝炎患者的临床症状、体征、肝功能、乙型肝炎病毒血清标志物水平、肝纤维化血清标志物水平 ,分析老年慢性乙型肝炎的临床特点 ;观察治疗组中血栓通过上述指标的影响 ,与对照组比较 ,进行统计学分析。结果 :老年慢性乙型肝炎患者临床症状以乏力、胁痛为主 ,部分病人可有食欲减退 ;多为HBeAg阴性 ,肝纤维化血清标志物普遍升高 ,肝功能损害多在轻至中度 ,多数有早期肝硬化表现。血栓通能改善患者乏力、胁痛、脾大等症状和体征 ,促进腹水消退 ,改善肝功能 ,降低肝纤维化血清标志物水平。结论 :老年慢性乙型肝炎的临床症状、体征及肝功能损害等多与气滞血瘀有关 ,血栓通的临床作用可能与其活血化瘀功能有关。
Objective: To observe the clinical features of senile chronic hepatitis B and the therapeutic effect of Xueshuantong, and to explore the mechanism of action of Xueshuantong against hepatic fibrosis. Methods: Clinical symptoms, signs, liver function, serum markers of hepatitis B virus (HBV) and serum markers of liver fibrosis were observed in 63 elderly patients with chronic hepatitis B. The clinical features of elderly chronic hepatitis B were observed. Thrombosis in the impact of the above indicators, compared with the control group for statistical analysis. Results: The clinical symptoms of elderly patients with chronic hepatitis B were fatigue and hypochondriac pain. Some patients had loss of appetite. Most of them were negative for HBeAg. Serum markers of liver fibrosis generally increased, liver dysfunction was mild to moderate, Most have early liver cirrhosis performance. Xueshuantong can improve symptoms and signs of fatigue, hypochondriac pain, splenomegaly and other symptoms, promote the regression of ascites, improve liver function and reduce the level of serum markers of liver fibrosis. Conclusion: Clinical symptoms, signs and liver damage in senile chronic hepatitis B are mostly related to qi stagnation and blood stasis. The clinical effect of thrombosis may be related to its function of promoting blood circulation and removing blood stasis.