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目的:探讨大网膜瓣包绕消化系吻合口在防治糖尿病大鼠消化系吻合口漏的疗效.方法:♂Wistar大鼠30只,适应饲养环境1 wk,采用高糖高脂饮食喂养2 mo后联合腹腔注射小剂量链脲佐菌素(35 mg/kg)制备2型糖尿病(type 2 diabetes mellitus,T2DM)大鼠模型,模型稳定7 d后分两组进行胃肠道手术,对照组(大网膜未包绕吻合口残端,n=11)和实验组(大网膜包绕吻合口,n=13).结果:对照组吻合口漏发生率为27.3%,实验组吻合口漏发生率为3.8%,与对照组相比明显降低(P=0.029),大鼠存活率显著提高.结论:大网膜瓣包绕吻合口预防胃肠道手术后吻合口漏是可行的,采用大网膜瓣包绕吻合口可显著降低糖尿病大鼠胃肠道手术吻合口漏的发生,提高大鼠存活率.
Objective: To investigate the curative effect of anastomosis of the large omental flap surrounded by digestive system on the prevention and treatment of digestive tract anastomotic leakage in diabetic rats.Methods: Thirty Wistar rats were adapted to the feeding environment for 1 wk and fed with high glucose and high fat diet for 2 months The model of type 2 diabetes mellitus (T2DM) was established by intraperitoneal injection of low dose of streptozotocin (35 mg / kg). The model was stable for 7 days and then divided into two groups for gastrointestinal surgery. The control group ( The omentum was not wrapped around the anastomotic stump, n = 11) and the experimental group (anastomosis omentum wrapping, n = 13) .Results: The incidence of anastomotic leakage in the control group was 27.3% (P = 0.029), and the survival rate of rats was significantly increased.Conclusion: Ovariectomy is an effective method to prevent anastomotic leakage after gastrointestinal surgery.Using Omentum wrapping anastomosis can significantly reduce the occurrence of gastrointestinal tract anastomotic leakage in diabetic rats and improve the survival rate of rats.